The Gryphons fell 70-65 to the McMaster Marauders on Saturday in Hamilton.
The majority of the first quarter was a back and forth effort, until the Marauders went on a late run to finish with a 21-14 lead at the end of the quarter.
Guelph dominated the second quarter, scoring 19 points and taking the lead heading into the second half.
McMaster regained the lead in the third quarter, setting them up with a seven-point lead (57-50) heading into the final ten minutes of play. The Marauders were up 66-56 at 3:30, but by 1:30, Guelph had narrowed the score, and with a three-point shot by Ali Dzikowski (Brantford, Ont.), the Marauders only led by three. The Marauders showed grit in the final minute and managed to maintain possession and run down the clock.
Ali Dzikowski (Brantford, Ont.) led Guelph with 20 points while Jasmine Douglas (Guelph, Ont.) had 18 and Kayla Goodhoofd (Oakville, Ont.) eight.
The Gryphons have lost four of the past five games and drop to 8-8 on the season.
Guelph hits the road for a pair of games this week against Windsor on Wednesday and Western on Saturday.